Central Catheter–Associated Bloodstream Infection Reduction With Ethanol Lock Prophylaxis in Pediatric Intestinal Failure

Ethanol Lock Treatment and Secondary Prophylaxis for Central Line-Associated Bloodstream Infection in Pediatric Hematology and Oncology: A Randomized, Double-Blind, Placebo-Controlled, Intervention Trial

Efficacy of ethanol locks in reducing central venous catheter infections in pediatric patients with intestinal failure.

PURPOSE We sought to determine whether a regimen of 70% ethanol locks could reduce the rate of central venous catheter (CVC) infections in parenteral nutrition-dependent children with intestinal failure. METHODS We performed a retrospective review of 23 parenteral nutrition-dependent children in our multidisciplinary intestinal rehabilitation clinic who started ethanol lock therapy between Se...

864A Prospective Study of Ethanol Lock Therapy in Children with Central Line-associated Bloodstream Infections

Line-associated Bloodstream Infections Tomohiro Katsuta, MD, PhD; Takumi Moriuchi, MD; Ayano Shinagawa, MD; Ryo Niiya, MD; Yusuke Miyaji, MD, PhD; Yukitsugu Nakamura, MD, PhD; Junichiro Tsuruoka, MD; Satoshi Tateyama, MD; Tadaomi Tokutake, MD, PhD; Natsuki Nakajima, MD, PhD; Toshiro Goshima, MD, PhD; Hitoshi Yamamoto, MD, PhD; Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan

Adjunctive management of central line-associated bloodstream infections with 70% ethanol-lock therapy.

OBJECTIVES Ethanol is bactericidal against most pathogens implicated in central line-associated bloodstream infections (CLABSIs) and biofilms. Current Infectious Diseases Society of America guidelines cite insufficient evidence to support adjunctive ethanol-lock therapy (ELT) for central venous catheter (CVC) salvage in patients with CLABSI in combination with systemic antimicrobial treatment. ...

Preemptive Ethanol Lock Therapy in Pediatric Hematology/Oncology Patients With Catheter-Associated Bloodstream Infection: Impact on Length of Stay, Cost, and Catheter Salvage

BACKGROUND Ethanol lock therapy (ELT) with systemic antimicrobial therapy is a promising therapy for catheter-related infection (CRI). The impact of ELT timing on treatment efficacy and costs is unknown. PROCEDURES A prospective study was conducted in the Hematology/Oncology Unit at the Children's Hospital of Michigan. Patients with suspected CRI were randomized to Preemptive ELT arm or Rescu...